Graduate Statistics Seminar
Qingyang Zhang
Northwestern
Integrative network analysis of TCGA data for ovarian cancer
Abstract: Traditional cancer studies have been mainly focusing on single
gene or single type of data including mRNA expression, DNA methylation, copy number variation, and etc.
However, such analyses lack power to reveal the molecular mechanisms from the view of system
biology. In this talk, I will present an integrative framework to identify important genetic and epigenetic
features and to quantify the causal relations among these features. I will first talk about what is a Bayesian
Network and what the TCGA data looks like. Then I will introduce the proposed feature selector and Bayesian
Network model. Simulated and real data sets will be used for illustration.
Tuesday April 22, 2014 at 3:30 PM in SEO 636