Statistics and Data Science Seminar
Dr. Cong Han
TAP Pharmaceutical Products, Inc.
Experimental Design for Nonlinear Mixed-Effects Models with Application to Studies of HIV Dynamics
Abstract: This presentation will review design issues for studies of HIV dynamics that use a nonlinear mixed-effects model. A method based on a first-order approximation, used for similar design issues in
pharmacokinetics and pharmacodynamics, will be reviewed and discussed. Limitations of this method will be discussed and other methods will be described, including methods based on the exact
calculation of the Fisher information matrix and Bayesian methods, which, although computationally intensive, provide alternatives.
Wednesday March 5, 2008 at 3:30 PM in SEO 712